| First Author | Zhao JL | Year | 2011 |
| Journal | Proc Natl Acad Sci U S A | Volume | 108 |
| Issue | 22 | Pages | 9184-9 |
| PubMed ID | 21576471 | Mgi Jnum | J:173230 |
| Mgi Id | MGI:5013656 | Doi | 10.1073/pnas.1105398108 |
| Citation | Zhao JL, et al. (2011) NF-{kappa}B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A 108(22):9184-9 |
| abstractText | MicroRNA miR-146a has been implicated as a negative feedback regulator of NF-kappaB activation. Knockout of the miR-146a gene in C57BL/6 mice leads to histologically and immunophenotypically defined myeloid sarcomas and some lymphomas. The sarcomas are transplantable to immunologically compromised hosts, showing that they are true malignancies. The animals also exhibit chronic myeloproliferation in their bone marrow. Spleen and marrow cells show increased transcription of NF-kappaB-regulated genes and tumors have higher nuclear p65. Genetic ablation of NF-kappaB p50 suppresses the myeloproliferation, showing that dysregulation of NF-kappaB is responsible for the myeloproliferative disease. |
