| First Author | Yang L | Year | 2012 |
| Journal | J Exp Med | Volume | 209 |
| Issue | 9 | Pages | 1655-70 |
| PubMed ID | 22891274 | Mgi Jnum | J:191831 |
| Mgi Id | MGI:5463175 | Doi | 10.1084/jem.20112218 |
| Citation | Yang L, et al. (2012) miR-146a controls the resolution of T cell responses in mice. J Exp Med 209(9):1655-70 |
| abstractText | T cell responses in mammals must be tightly regulated to both provide effective immune protection and avoid inflammation-induced pathology. NF-kappaB activation is a key signaling event induced by T cell receptor (TCR) stimulation. Dysregulation of NF-kappaB is associated with T cell-mediated inflammatory diseases and malignancies, highlighting the importance of negative feedback control of TCR-induced NF-kappaB activity. In this study we show that in mice, T cells lacking miR-146a are hyperactive in both acute antigenic responses and chronic inflammatory autoimmune responses. TCR-driven NF-kappaB activation up-regulates the expression of miR-146a, which in turn down-regulates NF-kappaB activity, at least partly through repressing the NF-kappaB signaling transducers TRAF6 and IRAK1. Thus, our results identify miR-146a as an important new member of the negative feedback loop that controls TCR signaling to NF-kappaB. Our findings also add microRNA to the list of regulators that control the resolution of T cell responses. |
