| First Author | Goten C | Year | 2023 |
| Journal | Int J Mol Sci | Volume | 24 |
| Issue | 3 | PubMed ID | 36768190 |
| Mgi Jnum | J:355305 | Mgi Id | MGI:7436810 |
| Doi | 10.3390/ijms24031868 | Citation | Goten C, et al. (2023) Important Role of Endogenous Nerve Growth Factor Receptor in the Pathogenesis of Hypoxia-Induced Pulmonary Hypertension in Mice. Int J Mol Sci 24(3) |
| abstractText | Pulmonary arterial hypertension (PAH) remains a disease with poor prognosis; thus, a new mechanism for PAH treatment is necessary. Circulating nerve growth factor receptor (Ngfr)-positive cells in peripheral blood mononuclear cells are associated with disease severity and the prognosis of PAH patients; however, the role of Ngfr in PAH is unknown. In this study, we evaluated the function of Ngfr using Ngfr gene-deletion (Ngfr(-/-)) mice. To elucidate the role of Ngfr in pulmonary hypertension (PH), we used Ngfr(-/-) mice that were exposed to chronic hypoxic conditions (10% O(2)) for 3 weeks. The development of hypoxia-induced PH was accelerated in Ngfr(-/-) mice compared to littermate controls. In contrast, the reconstitution of bone marrow (BM) in Ngfr(-/-) mice transplanted with wild-type BM cells improved PH. Notably, the exacerbation of PH in Ngfr(-/-) mice was accompanied by the upregulation of pulmonary vascular remodeling-related genes in lung tissue. In a hypoxia-induced PH model, Ngfr gene deletion resulted in PH exacerbation. This suggests that Ngfr may be a key molecule involved in the pathogenesis of PAH. |
