| First Author | Deppmann CD | Year | 2008 |
| Journal | Science | Volume | 320 |
| Issue | 5874 | Pages | 369-73 |
| PubMed ID | 18323418 | Mgi Jnum | J:133953 |
| Mgi Id | MGI:3784683 | Doi | 10.1126/science.1152677 |
| Citation | Deppmann CD, et al. (2008) A model for neuronal competition during development. Science 320(5874):369-73 |
| abstractText | We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its own receptor TrkA in mouse and rat neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain-derived neurotrophic factor and neurotrophin-4, which, through the receptor p75, can kill neighboring neurons with low retrograde NGF-TrkA signaling whereas neurons with high NGF-TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects. |
