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Allele : Nos1<tm1Plh> nitric oxide synthase 1, neuronal; targeted mutation 1, Paul L Huang
Primary Identifier  MGI:1857227 Allele Type  Targeted
Attribute String  Null/knockout Gene  Nos1
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin cassette replaced exon 1. This exon encodes the initiation site and amino acids 1 - 159 of the protein. Northern blots of brain homogenates from homozygous mutant mice showed no detectable mRNA. Western blots of brain homogenates from homozygous mutant mice showed no detectable protein. However, splice variants are expressed and variable low levels of NOS activity are seen in the brain.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • NOS<delta>,
  • alphaNOS1,
  • nNOS-,
  • N2KO,
  • alphaNOS1,
  • NOS<delta>,
  • Kn,
  • nNOS KO,
  • nNOS KO,
  • Kn,
  • nNOS<->,
  • nNOS-,
  • N2KO,
  • nNOS<->
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

5 Carried By

0 Driven By

299 Publication categories





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