| First Author | Moraes JC | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 19 | Pages | 4625-31 |
| PubMed ID | 16876161 | Mgi Jnum | J:112153 |
| Mgi Id | MGI:3655592 | Doi | 10.1016/j.febslet.2006.07.042 |
| Citation | Moraes JC, et al. (2006) Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake. FEBS Lett 580(19):4625-31 |
| abstractText | TNF-alpha acts on the hypothalamus modulating food intake and energy expenditure through mechanisms incompletely elucidated. Here, we explore the hypothesis that, to modulate insulin-induced anorexigenic signaling in hypothalamus, TNF-alpha requires the synthesis of NO. TNF-alpha activates signal transduction through JNK and p38 in hypothalamus, peaking at 10(-8) M. This is accompanied by the induction of expression of the inducible and neuronal forms of NOS, in both cases peaking at 10(-12) M. In addition, TNF-alpha stimulates NOS catalytic activity. Pre-treatment with TNF-alpha at a low dose (10(-12) M) inhibits insulin-dependent anorexigenic signaling, and this effect is abolished in iNOS but not in nNOS knockout mice. |
