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Publication : Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.

First Author  Adams LB Year  2000
Journal  Infect Immun Volume  68
Issue  9 Pages  5462-5
PubMed ID  10948185 Mgi Jnum  J:64036
Mgi Id  MGI:1888622 Doi  10.1128/iai.68.9.5462-5465.2000
Citation  Adams LB, et al. (2000) Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice. Infect Immun 68(9):5462-5
abstractText  The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.
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