| First Author | Caputa G | Year | 2022 |
| Journal | Cell Metab | Volume | 34 |
| Issue | 5 | Pages | 747-760.e6 |
| PubMed ID | 35508110 | Mgi Jnum | J:339140 |
| Mgi Id | MGI:7286141 | Doi | 10.1016/j.cmet.2022.04.008 |
| Citation | Caputa G, et al. (2022) Intracellular infection and immune system cues rewire adipocytes to acquire immune function. Cell Metab 34(5):747-760.e6 |
| abstractText | Adipose tissue (AT) plays a central role in systemic metabolic homeostasis, but its function during bacterial infection remains unclear. Following subcutaneous bacterial infection, adipocytes surrounding draining lymph nodes initiated a transcriptional response indicative of stimulation with IFN-gamma and a shift away from lipid metabolism toward an immunologic function. Natural killer (NK) and invariant NK T (iNKT) cells were identified as sources of infection-induced IFN-gamma in perinodal AT (PAT). IFN-gamma induced Nos2 expression in adipocytes through a process dependent on nuclear-binding oligomerization domain 1 (NOD1) sensing of live intracellular bacteria. iNOS expression was coupled to metabolic rewiring, inducing increased diversion of extracellular L-arginine through the arginosuccinate shunt and urea cycle to produce nitric oxide (NO), directly mediating bacterial clearance. In vivo, control of infection in adipocytes was dependent on adipocyte-intrinsic sensing of IFN-gamma and expression of iNOS. Thus, adipocytes are licensed by innate lymphocytes to acquire anti-bacterial functions during infection. |
