| First Author | Zaragoza C | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 10 | Pages | 5497-504 |
| PubMed ID | 10553076 | Mgi Jnum | J:58451 |
| Mgi Id | MGI:1347681 | Doi | 10.4049/jimmunol.163.10.5497 |
| Citation | Zaragoza C, et al. (1999) Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol 163(10):5497-504 |
| abstractText | Coxsackievirus infection causes myocarditis and pancreatitis in humans. In certain strains of mice, Coxsackievirus causes a severe pancreatitis. We explored the role of NO in the host immune response to viral pancreatitis. Coxsackievirus replicates to higher titers in mice lacking NO synthase 2 (NOS2) than in wild-type mice, with particularly high viral titers and viral RNA levels in the pancreas. Mice lacking NOS have a severe, necrotizing pancreatitis, with elevated pancreatic enzymes in the blood and necrotic acinar cells. Lack of NOS2 leads to a rapid increase in the mortality of infected mice. Thus, NOS2 is a critical component in the immune response to Coxsackievirus infection. |
