| First Author | Montoya M | Year | 2006 |
| Journal | Eur J Immunol | Volume | 36 |
| Issue | 8 | Pages | 2150-8 |
| PubMed ID | 16856204 | Mgi Jnum | J:113135 |
| Mgi Id | MGI:3664601 | Doi | 10.1002/eji.200535304 |
| Citation | Montoya M, et al. (2006) CD45 is required for type I IFN production by dendritic cells. Eur J Immunol 36(8):2150-8 |
| abstractText | CD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45(+/+), CD45(-/-), CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in CD45(-/-) mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up-regulation of MHC and costimulatory molecules. DC of CD45(-/-) mice have an impaired capacity to produce type I interferons in response to LCMV infection in vivo. These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes. |
