| First Author | Virts EL | Year | 2003 |
| Journal | Blood | Volume | 101 |
| Issue | 3 | Pages | 849-55 |
| PubMed ID | 12393487 | Mgi Jnum | J:115557 |
| Mgi Id | MGI:3691925 | Doi | 10.1182/blood-2002-07-1969 |
| Citation | Virts EL, et al. (2003) A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency. Blood 101(3):849-55 |
| abstractText | Transgenic mice have been generated that carry a CD45 minigene under control of the human leukocyte function-associated antigen (LFA-1, CD11a) promoter. CD45-null mice carrying the transgene exhibit the lymphocyte lineage-specific isoform expression patterns of wild-type mice. Furthermore, these mice have normal thymocyte development and peripheral T-cell numbers. The proliferative ability of T cells in response to mitogens and antigen also is regained, as is B-cell responsiveness to anti-IgM. The antibody response to antigen is also restored and is similar to that of normal mice. Therefore, introduction of a functional CD45 minigene is sufficient to overcome the principal severe combined immunodeficiency (SCID)-associated defects and represents a potential route to a gene therapy for human CD45-deficent SCID. |
