| First Author | Kirkwood A | Year | 1997 |
| Journal | Proc Natl Acad Sci U S A | Volume | 94 |
| Issue | 7 | Pages | 3380-3 |
| PubMed ID | 9096402 | Mgi Jnum | J:39398 |
| Mgi Id | MGI:86779 | Doi | 10.1073/pnas.94.7.3380 |
| Citation | Kirkwood A, et al. (1997) Age-dependent decrease of synaptic plasticity in the neocortex of alphaCaMKII mutant mice. Proc Natl Acad Sci U S A 94(7):3380-3 |
| abstractText | Synaptic long-term potentiation (LTP) and long-term depression (LTD) were studied in the visual cortex of mutant mice lacking alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII). In adult mutants, little LTD or LTP could be elicited using standard conditioning protocols. However, substantial LTD and LTP were induced in 4- to 5-week-old mutants. Thus, the reduction in cortical plasticity in alphaCaMKII (-/-) mice is conditional, with the relevant condition being postnatal age. |
