| First Author | Geng Y | Year | 1999 |
| Journal | Cell | Volume | 97 |
| Issue | 6 | Pages | 767-77 |
| PubMed ID | 10380928 | Mgi Jnum | J:55690 |
| Mgi Id | MGI:1339212 | Doi | 10.1016/s0092-8674(00)80788-6 |
| Citation | Geng Y, et al. (1999) Rescue of cyclin D1 deficiency by knockin cyclin E. Cell 97(6):767-77 |
| abstractText | D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1. |
