| First Author | Choi YJ | Year | 2012 |
| Journal | Cancer Cell | Volume | 22 |
| Issue | 4 | Pages | 438-51 |
| PubMed ID | 23079655 | Mgi Jnum | J:192032 |
| Mgi Id | MGI:5463836 | Doi | 10.1016/j.ccr.2012.09.015 |
| Citation | Choi YJ, et al. (2012) The requirement for cyclin D function in tumor maintenance. Cancer Cell 22(4):438-51 |
| abstractText | D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains that allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D-associated kinase activity in mice bearing ErbB2-driven mammary carcinomas triggered tumor cell senescence, without compromising the animals' health. Ablation of cyclin D3 in mice bearing Notch1-driven T cell acute lymphoblastic leukemias (T-ALL) triggered tumor cell apoptosis. Such selective killing of leukemic cells can also be achieved by inhibiting cyclin D associated kinase activity in mouse and human T-ALL models. Inhibition of cyclin D-kinase activity represents a highly-selective anticancer strategy that specifically targets cancer cells without significantly affecting normal tissues. |
