| First Author | Locksley RM | Year | 1993 |
| Journal | Science | Volume | 261 |
| Issue | 5127 | Pages | 1448-51 |
| PubMed ID | 8367726 | Mgi Jnum | J:113010 |
| Mgi Id | MGI:3664188 | Doi | 10.1126/science.8367726 |
| Citation | Locksley RM, et al. (1993) Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261(5127):1448-51 |
| abstractText | Expression of either the CD4 or CD8 glycoproteins discriminates two functionally distinct lineages of T lymphocytes. A null mutation in the gene encoding CD4 impairs the development of the helper cell lineage that is normally defined by CD4 expression. Infection of CD4-null mice with Leishmania has revealed a population of functional helper T cells that develops despite the absence of CD4. These CD8- alpha beta T cell receptor+ T cells are major histocompatibility complex class II-restricted and produce interferon-gamma when challenged with parasite antigens. These results indicate that T lymphocyte lineage commitment and peripheral function need not depend on the function of CD4. |
