| First Author | Jones-Mason ME | Year | 2012 |
| Journal | Immunity | Volume | 36 |
| Issue | 3 | Pages | 348-61 |
| PubMed ID | 22425249 | Mgi Jnum | J:187334 |
| Mgi Id | MGI:5436206 | Doi | 10.1016/j.immuni.2012.02.010 |
| Citation | Jones-Mason ME, et al. (2012) E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348-61 |
| abstractText | The double-positive (DP) to single-positive (SP) transition during T cell development is initiated by downregulation of the E protein transcription factors HEB and E2A. Here, we have demonstrated that in addition to regulating the onset of this transition, HEB and E2A also play a separate role in CD4(+) lineage choice. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development. Analysis of the CD4(+) lineage transcriptional regulators ThPOK and Gata3 placed HEB and E2A upstream of CD4(+) lineage specification. These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition. |
