| First Author | Strong J | Year | 2001 |
| Journal | Proc Natl Acad Sci U S A | Volume | 98 |
| Issue | 5 | Pages | 2566-71 |
| PubMed ID | 11226279 | Mgi Jnum | J:67872 |
| Mgi Id | MGI:1931645 | Doi | 10.1073/pnas.051329698 |
| Citation | Strong J, et al. (2001) Impaired survival of T helper cells in the absence of CD4. Proc Natl Acad Sci U S A 98(5):2566-71 |
| abstractText | Signal transduction in response to ligand recognition by T cell receptors regulates T cell fate within and beyond the thymus. Herein we examine the involvement of the CD4 molecule in the regulation of T helper cell survival. T helper cells that lack CD4 expression are prone to apoptosis and show diminished survival after adoptive transfer to irradiated recipients. The helper lineage in CD4(-/-) animals shows a higher than normal apparent rate of cell division and is also enriched for cells exhibiting a memory cell phenotype. Thus the data point to a necessary role for CD4 in the regulation of T helper cell survival and homeostasis. |
