| First Author | Adleman LM | Year | 1996 |
| Journal | J Acquir Immune Defic Syndr Hum Retrovirol | Volume | 11 |
| Issue | 4 | Pages | 334-40 |
| PubMed ID | 8601219 | Mgi Jnum | J:34682 |
| Mgi Id | MGI:82136 | Doi | 10.1097/00042560-199604010-00003 |
| Citation | Adleman LM, et al. (1996) Blind T-cell homeostasis in CD4-deficient mice. J Acquir Immune Defic Syndr Hum Retrovirol 11(4):334-40 |
| abstractText | Recently, it has been proposed that normal T-cell count is maintained by a homeostatic mechanism which is blind to the distinction between CD4+ T cells and CD8+ T cells. Interest in this blind homeostasis hypothesis (BHH) stems in part from its implications regarding the pathogenesis and treatment of HIV infection. In this report, BHH was tested in CD4-deficient mice. We found that as predicted by BHH, despite the absence of CD4+ T cells, CD4-deficient mice maintain normal absolute T-cell counts in the blood and spleen primarily through a marked increase in CD8+ T cells. These findings provide strong new support for BHH. |
