| First Author | Müller U | Year | 1994 |
| Journal | Science | Volume | 264 |
| Issue | 5167 | Pages | 1918-21 |
| PubMed ID | 8009221 | Mgi Jnum | J:36115 |
| Mgi Id | MGI:83477 | Doi | 10.1126/science.8009221 |
| Citation | Muller U, et al. (1994) Functional role of type I and type II interferons in antiviral defense. Science 264(5167):1918-21 |
| abstractText | Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant. |
