| First Author | Dunn GP | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 7 | Pages | 722-9 |
| PubMed ID | 15951814 | Mgi Jnum | J:99146 |
| Mgi Id | MGI:3581343 | Doi | 10.1038/ni1213 |
| Citation | Dunn GP, et al. (2005) A critical function for type I interferons in cancer immunoediting. Nat Immunol 6(7):722-9 |
| abstractText | 'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-gamma (IFN-gamma) is known to be involved in this process, the involvement of type I interferons (IFN-alpha/beta) has not been elucidated. We now show that, like IFN-gamma, endogenously produced IFN-alpha/beta was required for the prevention of the growth of primary carcinogen-induced and transplantable tumors. Although tumor cells are important IFN-gamma targets, they are not functionally relevant sites of the actions of the type I interferons. Instead, host hematopoietic cells are critical IFN-alpha/beta targets during development of protective antitumor responses. Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma. |
