| First Author | Frey U | Year | 1996 |
| Journal | J Neurosci | Volume | 16 |
| Issue | 6 | Pages | 2057-63 |
| PubMed ID | 8604050 | Mgi Jnum | J:110861 |
| Mgi Id | MGI:3641403 | Doi | 10.1523/JNEUROSCI.16-06-02057.1996 |
| Citation | Frey U, et al. (1996) A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice. J Neurosci 16(6):2057-63 |
| abstractText | The establishment of hippocampal long-term (LTP) requires protein and mRNA synthesis, suggesting that neuronal activity resulting in LTP initiates a cascade of gene expression. The expression of the gene for the extracellular serine protease tissue plasminogen activator (t-PA) is induced during LTP. Here we analyze long-lasting LTP (L-LTP,>4 hr)in CA1 hippocampal slices of mice homozygous for disrupted t-PA genes. Although mutant mice appear to exhibit long-term potentiation, we provide evidence that these mice are devoid of conventional homosynaptic L-LTP at the Schaffer collateral-CA1 pyramidal cell synapse. Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor-dependent modification of GABA transmission in the CA1 region. |
