| First Author | Tucker HM | Year | 2004 |
| Journal | Neurosci Lett | Volume | 368 |
| Issue | 3 | Pages | 285-9 |
| PubMed ID | 15364412 | Mgi Jnum | J:120020 |
| Mgi Id | MGI:3703686 | Doi | 10.1016/j.neulet.2004.07.011 |
| Citation | Tucker HM, et al. (2004) Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neurosci Lett 368(3):285-9 |
| abstractText | Deposition of amyloid beta (A beta) into extracellular plaques is a pathologic characteristic of Alzheimer's disease. Plasmin, neprilysin, endothelin-converting enzyme and insulin-degrading enzyme (IDE) have each been implicated in A beta degradation; data supporting the role of the latter three enzymes have included increased levels of endogenous murine A beta in mice genetically deficient for the respective enzyme. In this study, we sought to determine if plasminogen deficiency increases endogenous A beta. We report that plasminogen deficiency did not result in an A beta increase in the brain or in the plasma of adult mice. Hence, although plasmin is potentially important in the degradation of A beta aggregates, we interpret these data as suggesting that plasmin does not regulate steady-state A beta levels in non-pathologic conditions. |
