| First Author | Penkowa M | Year | 2003 |
| Journal | Cell Mol Life Sci | Volume | 60 |
| Issue | 1 | Pages | 185-97 |
| PubMed ID | 12613667 | Mgi Jnum | J:115509 |
| Mgi Id | MGI:3691877 | Doi | 10.1007/s000180300013 |
| Citation | Penkowa M, et al. (2003) Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis. Cell Mol Life Sci 60(1):185-97 |
| abstractText | Metallothioneins I+II (MT-I+II) are antioxidant, neuroprotective factors. We previously showed that MT-I+II deficiency during experimental autoimmune encephalomyelitis (EAE) leads to increased disease incidence and clinical symptoms. Moreover, the inflammatory response of macrophages and T cells, oxidative stress, and apoptotic cell death during EAE were increased by MT-I+II deficiency. We now show for the first time that demyelination and axonal damage are significantly increased in MT-I+II deficient mice during EAE. Furthermore, oligodendroglial regeneration, growth cone formation, and tissue repair including expression of trophic factors were significantly reduced in MT-I+II-deficient mice during EAE. Accordingly, MT-I+II have protective and regenerative roles in the brain. |
