| First Author | Asanuma M | Year | 2002 |
| Journal | Neurosci Lett | Volume | 327 |
| Issue | 1 | Pages | 61-5 |
| PubMed ID | 12098501 | Mgi Jnum | J:107961 |
| Mgi Id | MGI:3622596 | Doi | 10.1016/s0304-3940(02)00346-4 |
| Citation | Asanuma M, et al. (2002) Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain. Neurosci Lett 327(1):61-5 |
| abstractText | The effects of two major isoforms of metallothioneins (MTs), MT-I and -II, on dopaminergic neurotoxicity of 6-hydroxydopamine (6-OHDA) were examined using intracerebroventricularly 6-OHDA-injected MT-I, II knock-out (KO) mice. The loss of dopamine neurons in the substantia nigra pars compacta induced by the 6-OHDA injection was significantly aggravated in the MT-I, II KO mice, compared with that in the 6-OHDA-injected wild-type mice. The present results, taken together with the antioxidant properties of MT-I and -II suggest that MT-I and -II exert neuroprotective effects against the dopaminergic neurotoxicity of 6-OHDA at the nigral cell body by scavenging free radicals. |
