| First Author | Weinstein MM | Year | 2010 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 30 |
| Issue | 1 | Pages | 20-3 |
| PubMed ID | 19815815 | Mgi Jnum | J:171805 |
| Mgi Id | MGI:4999721 | Doi | 10.1161/ATVBAHA.109.196329 |
| Citation | Weinstein MM, et al. (2010) Chylomicronemia elicits atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol 30(1):20-3 |
| abstractText | OBJECTIVE: The risk of atherosclerosis in the setting of chylomicronemia has been a topic of debate. In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis. METHODS AND RESULTS: Gpihbp1(-/-) mice on a chow diet have plasma triglyceride and cholesterol levels of 2812+/-209 and 319+/-27 mg/dL, respectively. Even though nearly all of the lipids were contained in large lipoproteins (50 to 135 nm), the mice developed progressive aortic atherosclerosis. In other experiments, we found that both Gpihbp1-deficient 'apo-B48-only' mice and Gpihbp1-deficient 'apo-B100-only' mice manifest severe chylomicronemia. Thus, GPIHBP1 is required for the processing of both apo-B48- and apo-B100-containing lipoproteins. CONCLUSIONS: Chylomicronemia causes atherosclerosis in mice. Also, we found that GPIHBP1 is required for the lipolytic processing of both apo-B48- and apo-B100-containing lipoproteins. |
