| First Author | Griffin CT | Year | 2001 |
| Journal | Science | Volume | 293 |
| Issue | 5535 | Pages | 1666-70 |
| PubMed ID | 11533492 | Mgi Jnum | J:71309 |
| Mgi Id | MGI:2149536 | Doi | 10.1126/science.1061259 |
| Citation | Griffin CT, et al. (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science 293(5535):1666-70 |
| abstractText | The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development. Approximately half of Par1-/- mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene driven by an endothelial-specific promoter prevented death of Par1-/- embryos. Our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo. |
