| First Author | Robertson KE | Year | 1996 |
| Journal | Dev Genet | Volume | 19 |
| Issue | 1 | Pages | 9-25 |
| PubMed ID | 8792605 | Mgi Jnum | J:35173 |
| Mgi Id | MGI:82623 | Doi | 10.1002/(SICI)1520-6408(1996)19:1<9::AID-DVG2>3.0.CO;2-D |
| Citation | Robertson KE, et al. (1996) Cellular analysis of limb development in the mouse mutant hypodactyly. Dev Genet 19(1):9-25 |
| abstractText | The limb defect in the mouse Hypodactyly (Hd) affects only the distal structures. Heterozygotes (Hd/+) lack all or part of the distal phalanx and the terminal claw of digit I on the hindlimbs; mice homozygous (Hd/Hd) for the mutation have lust one digit on each of the four limbs. Early limb development in the mutant appears normal and a change in morphology can only be detected later. Limb buds of Hd/+ and Hd/Hd embryos become reduced in width, with Hd/ Hd buds becoming very pointed instead of rounded. This change in bud shape is correlated with an increase in cell death anteriorly in Hd/+ hindlimbs and both anteriorly and posteriorly in Hd/Hd fore- and hindlimb buds. The apical ectodermal ridge is very pronounced in pointed Hd/Hd limb buds. Mesenchyme cells from the Hd/Hd mutant in culture show a cell-autonomous change in behaviour and less cartilage differentiates. (C) 1996 Wiley-Liss, Inc. |
