| First Author | Wang X | Year | 2015 |
| Journal | Cancer Cell | Volume | 28 |
| Issue | 3 | Pages | 296-306 |
| PubMed ID | 26321222 | Mgi Jnum | J:225959 |
| Mgi Id | MGI:5695389 | Doi | 10.1016/j.ccell.2015.07.014 |
| Citation | Wang X, et al. (2015) IL-36gamma Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. Cancer Cell 28(3):296-306 |
| abstractText | Cytokines play a pivotal role in regulating tumor immunogenicity and antitumor immunity. IL-36gamma is important for the IL-23/IL-17-dominated inflammation and anti-BCG Th1 immune responses. However, the impact of IL-36gamma on tumor immunity is unknown. Here we found that IL-36gamma stimulated CD8(+) T cells, NK cells, and gammadelta T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36gamma exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. Furthermore, IL-36gamma strongly increased the efficacy of tumor vaccination. Moreover, IL-36gamma expression inversely correlated with the progression of human melanoma and lung cancer. Our study establishes a role of IL-36gamma in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy. |
