| First Author | Bolitho P | Year | 2009 |
| Journal | Proc Natl Acad Sci U S A | Volume | 106 |
| Issue | 8 | Pages | 2723-8 |
| PubMed ID | 19196996 | Mgi Jnum | J:146488 |
| Mgi Id | MGI:3837629 | Doi | 10.1073/pnas.0809008106 |
| Citation | Bolitho P, et al. (2009) Perforin-mediated suppression of B-cell lymphoma. Proc Natl Acad Sci U S A 106(8):2723-8 |
| abstractText | In the present study, we have examined the effect of perforin (pfp) deficiency in 4 models of mouse B-cell lymphomagenesis. We have examined pfp loss on the background of either Mlh1 tumor suppressor allele loss or oncogene expression [Ig heavy chain (Emu)-v-Abl, Emu-myc, and vav-bcl2]. Pfp was shown to act as a suppressor of B-cell malignancies characteristically driven by v-Abl or bcl-2, whereas Mlh loss cooperated in accelerating spontaneous B-cell lymphomas characteristic of pfp loss. No protective role for pfp was observed in the more aggressive Emu-myc model of B-cell lymphoma. These transgenic models have allowed us to distinguish the role of pfp in surveillance of B-cell lymphomagenesis, as opposed to its loss simply driving the onset of a spontaneous lymphoma characteristic of pfp deficiency. |
