| First Author | Singh TP | Year | 2021 |
| Journal | PLoS Pathog | Volume | 17 |
| Issue | 10 | Pages | e1009693 |
| PubMed ID | 34699567 | Mgi Jnum | J:312929 |
| Mgi Id | MGI:6792297 | Doi | 10.1371/journal.ppat.1009693 |
| Citation | Singh TP, et al. (2021) Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis. PLoS Pathog 17(10):e1009693 |
| abstractText | Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that maintain barrier function and can initiate a protective or pathological immune response upon infection. Here we show the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. IL-17A-producing ILCs were RORgammat+ and were enriched in Leishmania major infected skin, and topical colonization with Staphylococcus epidermidis before L. major infection exacerbated the skin inflammatory responses and IL-17A-producing RORgammat+ ILC accumulation without impacting type 1 immune responses. IL-17A responses in ILCs were directed by Batf3 dependent CD103+ dendritic cells and IL-23. Moreover, experiments using Rag1-/- mice established that IL-17A+ ILCs were sufficient in driving the inflammatory responses as depletion of ILCs or neutralization of IL-17A diminished the microbiota mediated immunopathology. Taken together, this study indicates that the skin microbiota promotes RORgammat+ IL-17A-producing ILCs, which augment the skin inflammation in cutaneous leishmaniasis. |
