| First Author | Kalafati L | Year | 2020 |
| Journal | Cell | Volume | 183 |
| Issue | 3 | Pages | 771-785.e12 |
| PubMed ID | 33125892 | Mgi Jnum | J:354537 |
| Mgi Id | MGI:6477714 | Doi | 10.1016/j.cell.2020.09.058 |
| Citation | Kalafati L, et al. (2020) Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell 183(3):771-785.e12 |
| abstractText | Trained innate immunity, induced via modulation of mature myeloid cells or their bone marrow progenitors, mediates sustained increased responsiveness to secondary challenges. Here, we investigated whether anti-tumor immunity can be enhanced through induction of trained immunity. Pre-treatment of mice with beta-glucan, a fungal-derived prototypical agonist of trained immunity, resulted in diminished tumor growth. The anti-tumor effect of beta-glucan-induced trained immunity was associated with transcriptomic and epigenetic rewiring of granulopoiesis and neutrophil reprogramming toward an anti-tumor phenotype; this process required type I interferon signaling irrespective of adaptive immunity in the host. Adoptive transfer of neutrophils from beta-glucan-trained mice to naive recipients suppressed tumor growth in the latter in a ROS-dependent manner. Moreover, the anti-tumor effect of beta-glucan-induced trained granulopoiesis was transmissible by bone marrow transplantation to recipient naive mice. Our findings identify a novel and therapeutically relevant anti-tumor facet of trained immunity involving appropriate rewiring of granulopoiesis. |
