| First Author | Chorro L | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 5368 |
| PubMed ID | 30560927 | Mgi Jnum | J:268677 |
| Mgi Id | MGI:6268133 | Doi | 10.1038/s41467-018-07806-6 |
| Citation | Chorro L, et al. (2018) Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape. Nat Commun 9(1):5368 |
| abstractText | Foxp3(+)CD4(+) regulatory T (Treg) cells are essential for preventing fatal autoimmunity and safeguard immune homeostasis in vivo. While expression of the transcription factor Foxp3 and IL-2 signals are both required for the development and function of Treg cells, the commitment to the Treg cell lineage occurs during thymic selection upon T cell receptor (TCR) triggering, and precedes the expression of Foxp3. Whether signals beside TCR contribute to establish Treg cell epigenetic and functional identity is still unknown. Here, using a mouse model with reduced IL-2 signaling, we show that IL-2 regulates the positioning of the pioneer factor SATB1 in CD4(+) thymocytes and controls genome wide chromatin accessibility of thymic-derived Treg cells. We also show that Treg cells receiving only low IL-2 signals can suppress endogenous but not WT autoreactive T cell responses in vitro and in vivo. Our findings have broad implications for potential therapeutic strategies to reprogram Treg cells in vivo. |
