| First Author | Vaeth M | Year | 2014 |
| Journal | J Exp Med | Volume | 211 |
| Issue | 3 | Pages | 545-61 |
| PubMed ID | 24590764 | Mgi Jnum | J:210738 |
| Mgi Id | MGI:5571779 | Doi | 10.1084/jem.20130604 |
| Citation | Vaeth M, et al. (2014) Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression. J Exp Med 211(3):545-61 |
| abstractText | Maturation of high-affinity B lymphocytes is precisely controlled during the germinal center reaction. This is dependent on CD4(+)CXCR5(+) follicular helper T cells (TFH) and inhibited by CD4(+)CXCR5(+)Foxp3(+) follicular regulatory T cells (TFR). Because NFAT2 was found to be highly expressed and activated in follicular T cells, we addressed its function herein. Unexpectedly, ablation of NFAT2 in T cells caused an augmented GC reaction upon immunization. Consistently, however, TFR cells were clearly reduced in the follicular T cell population due to impaired homing to B cell follicles. This was TFR-intrinsic because only in these cells NFAT2 was essential to up-regulate CXCR5. The physiological relevance for humoral (auto-)immunity was corroborated by exacerbated lupuslike disease in the presence of NFAT2-deficient TFR cells. |
