| First Author | Sun J | Year | 2009 |
| Journal | Nat Med | Volume | 15 |
| Issue | 3 | Pages | 277-84 |
| PubMed ID | 19234462 | Mgi Jnum | J:146782 |
| Mgi Id | MGI:3838440 | Doi | 10.1038/nm.1929 |
| Citation | Sun J, et al. (2009) Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med 15(3):277-84 |
| abstractText | Activated antigen-specific T cells produce a variety of effector molecules for clearing infection but also contribute to inflammation and tissue injury. Here we report an anti-inflammatory property of antiviral CD8+ and CD4+ effector T cells (T(eff) cells) in the infected periphery during acute virus infection. We find that, during acute influenza infection, interleukin-10 (IL-10) is produced in the infected lungs in large amounts--exclusively by infiltrating virus-specific T(eff) cells, with CD8+ T(eff) cells contributing a larger fraction of the IL-10 produced. These T(eff) cells in the periphery simultaneously produce IL-10 and proinflammatory cytokines and express lineage markers characteristic of conventional T helper type 1 or T cytotoxic type 1 cells. Notably, blocking the action of the T(eff) cell-derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral T(eff) cells exert regulatory functions--that is, they fine-tune the extent of lung inflammation and injury associated with influenza infection by producing an anti-inflammatory cytokine. We discuss the potential implications of these findings for infection with highly pathogenic influenza viruses. |
