| First Author | Ouyang W | Year | 2009 |
| Journal | Immunity | Volume | 30 |
| Issue | 3 | Pages | 358-71 |
| PubMed ID | 19285438 | Mgi Jnum | J:147057 |
| Mgi Id | MGI:3839177 | Doi | 10.1016/j.immuni.2009.02.003 |
| Citation | Ouyang W, et al. (2009) An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance. Immunity 30(3):358-71 |
| abstractText | Members of the Forkhead box O (Foxo) family of transcription factors are key regulators of cellular responses, but their function in the immune system remains incompletely understood. Here we showed that T cell-specific deletion of Foxo1 gene in mice led to spontaneous T cell activation, effector T cell differentiation, autoantibody production, and the induction of inflammatory bowel disease in a transfer model. In addition, Foxo1 was critical for the maintenance of naive T cells in the peripheral lymphoid organs. Transcriptome analyses of T cells identified Foxo1-regulated genes encoding, among others, cell-surface molecules, signaling proteins, and nuclear factors that control gene expression. Functional studies validated interleukin-7 receptor-alpha as a Foxo1 target gene essential for Foxo1 maintenance of naive T cells. These findings reveal crucial functions of Foxo1-dependent transcription in control of T cell homeostasis and tolerance. |
