| First Author | Erazo A | Year | 2007 |
| Journal | Immunity | Volume | 26 |
| Issue | 2 | Pages | 191-203 |
| PubMed ID | 17292640 | Mgi Jnum | J:118527 |
| Mgi Id | MGI:3699740 | Doi | 10.1016/j.immuni.2006.12.006 |
| Citation | Erazo A, et al. (2007) Unique Maturation Program of the IgE Response In Vivo. Immunity 26(2):191-203 |
| abstractText | A key event in the pathogenesis of asthma and allergies is the production of IgE antibodies. We show here that IgE(+) cells were exceptional because they were largely found outside germinal centers and expressed, from very early on, a genetic program of plasma cells. In spite of their extragerminal center localization, IgE(+) cells showed signs of somatic hypermutation and affinity maturation. We demonstrated that high-affinity IgE(+) cells could be generated through a unique differentiation program that involved two phases: a pre-IgE phase in which somatic hypermutation and affinity maturation take place in IgG1(+) cells, and a post-IgE-switching phase in which IgE cells differentiate swiftly into plasma cells. Our results have implications for the understanding of IgE memory responses in allergy. |
