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Publication : FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice.

First Author  Momenilandi M Year  2024
Journal  Cell Volume  187
Issue  11 Pages  2817-2837.e31
PubMed ID  38701783 Mgi Jnum  J:348742
Mgi Id  MGI:7643069 Doi  10.1016/j.cell.2024.04.009
Citation  Momenilandi M, et al. (2024) FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice. Cell 187(11):2817-2837.e31
abstractText  FMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors. Counts of B cells, monocytes, and DCs were low in the patients' blood, whereas the other blood subsets, including NK cells, were affected only moderately, if at all. The patients had normal counts of Langerhans cells (LCs) and dermal macrophages in the skin but lacked dermal DCs. Thus, FLT3L is required for B cell and DC development in mice and humans. However, unlike its murine counterpart, human FLT3L is required for the development of monocytes but not NK cells.
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