| First Author | Savage PA | Year | 2008 |
| Journal | Science | Volume | 319 |
| Issue | 5860 | Pages | 215-20 |
| PubMed ID | 18187659 | Mgi Jnum | J:131347 |
| Mgi Id | MGI:3773519 | Doi | 10.1126/science.1148886 |
| Citation | Savage PA, et al. (2008) Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science 319(5860):215-20 |
| abstractText | Substantial evidence exists that many tumors can be specifically recognized by CD8+ T lymphocytes. The definition of antigens targeted by these cells is paramount for the development of effective immunotherapeutic strategies for treating human cancers. In a screen for endogenous tumor-associated T cell responses in a primary mouse model of prostatic adenocarcinoma, we identified a naturally arising CD8+ T cell response that is reactive to a peptide derived from histone H4. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice. Thus, the repertoire of antigens recognized by tumor-infiltrating T cells is broader than previously thought and includes peptides derived from ubiquitous self antigens that are normally sequestered from immune detection. |
