| First Author | Cook DN | Year | 1995 |
| Journal | Science | Volume | 269 |
| Issue | 5230 | Pages | 1583-5 |
| PubMed ID | 7667639 | Mgi Jnum | J:28704 |
| Mgi Id | MGI:76248 | Doi | 10.1126/science.7667639 |
| Citation | Cook DN, et al. (1995) Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science 269(5230):1583-5 |
| abstractText | Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo. |
