| First Author | Subramaniam M | Year | 1996 |
| Journal | Blood | Volume | 87 |
| Issue | 4 | Pages | 1238-42 |
| PubMed ID | 8608210 | Mgi Jnum | J:31431 |
| Mgi Id | MGI:78939 | Doi | 10.1182/blood.v87.4.1238.bloodjournal8741238 |
| Citation | Subramaniam M, et al. (1996) Defects in hemostasis in P-selectin-deficient mice. Blood 87(4):1238-42 |
| abstractText | Recently, our laboratory showed that platelets, like leukocytes, roll on activated endothelium expressing P-selectin, thus suggesting a role for P-selectin in hemostasis (Frenette et at, Proc Natl Acad Sci USA 92:7450, 1995). We report here that the P-selectin--deficient mice show a 40% prolongation of the bleeding time on amputation of the tip of the tail. Moreover, defective hemostasis was observed in a local Shwartzman-like reaction induced by skin injections of lipopolysaccharide followed by tumor necrosis factor-alpha in the P-selectin--deficient mice. The hemorrhagic lesions, quantitated both macroscopically and microscopically, were twofold larger in the P-selectin--deficient mice. This was also confirmed by measuring the radioactivity in the skin using chromium-labeled red blood cells. Therefore, it is evident that P-selectin plays a role in hemostasis as suggested by its support of platelet rolling. |
