| First Author | Veerman KM | Year | 2007 |
| Journal | Nat Immunol | Volume | 8 |
| Issue | 5 | Pages | 532-9 |
| PubMed ID | 17401367 | Mgi Jnum | J:122420 |
| Mgi Id | MGI:3714254 | Doi | 10.1038/ni1456 |
| Citation | Veerman KM, et al. (2007) Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat Immunol 8(5):532-9 |
| abstractText | P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule. |
