| First Author | Wiedemann GM | Year | 2020 |
| Journal | Cell Rep | Volume | 33 |
| Issue | 11 | Pages | 108498 |
| PubMed ID | 33326784 | Mgi Jnum | J:304316 |
| Mgi Id | MGI:6694825 | Doi | 10.1016/j.celrep.2020.108498 |
| Citation | Wiedemann GM, et al. (2020) Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell Rep 33(11):108498 |
| abstractText | Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the roles of this transcription factor and its upstream cytokines interleukin-2 (IL-2) and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. We demonstrate that STAT5 is induced in NK cells by IL-12 and STAT4 early after infection and that partial STAT5 deficiency results in a defective capacity of NK cells to generate long-lived memory cells. Furthermore, we find a functional dichotomy of IL-2 and IL-15 signaling outputs during viral infection, whereby both cytokines drive clonal expansion, but only IL-15 is required for memory NK cell survival. We thus highlight a role for STAT5 signaling in promoting an optimal anti-viral NK cell response. |
