| First Author | Curtsinger JM | Year | 2005 |
| Journal | J Immunol | Volume | 174 |
| Issue | 8 | Pages | 4465-9 |
| PubMed ID | 15814665 | Mgi Jnum | J:98161 |
| Mgi Id | MGI:3577558 | Doi | 10.4049/jimmunol.174.8.4465 |
| Citation | Curtsinger JM, et al. (2005) Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-9 |
| abstractText | In this study, we show that IFN-alpha beta can have a direct role in linking innate and adaptive responses by providing the 'third signal' needed by naive CD8 T cells responding to Ag and costimulatory ligands. Stimulation of CD8 T cells in the absence of a third signal leads to proliferation, but clonal expansion is limited by poor survival and effector functions do not develop. We show that IFN-alpha beta can provide the third signal directly to CD8 T cells via a STAT4-dependent pathway to stimulate survival, development of cytolytic function, and production of IFN-gamma. Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function. |
