| First Author | Thieu VT | Year | 2008 |
| Journal | Immunity | Volume | 29 |
| Issue | 5 | Pages | 679-90 |
| PubMed ID | 18993086 | Mgi Jnum | J:143179 |
| Mgi Id | MGI:3823140 | Doi | 10.1016/j.immuni.2008.08.017 |
| Citation | Thieu VT, et al. (2008) Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity 29(5):679-90 |
| abstractText | Transcriptional regulatory networks direct the development of specialized cell types. The transcription factors signal tranducer and activator of transcription 4 (Stat4) and T-bet are required for the interleukin-12 (IL-12)-stimulated development of T helper 1 (Th1) cells, although the hierarchy of activity by these factors has not been clearly defined. In this report, we show that these factors did not function in a linear pathway and that each factor played a unique role in programming chromatin architecture for Th1 gene expression, with subsets of genes depending on Stat4, T-bet, or both for expression in Th1 cells. T-bet was not able to transactivate expression of Stat4-dependent genes in the absence of endogenous Stat4 expression. Thus, T-bet requires Stat4 to achieve complete IL-12-dependent Th1 cell-fate determination. These data provide a basis for understanding how transiently activated and lineage-specific transcription factors cooperate in promoting cellular differentiation. |
