| First Author | Martien van Santen H | Year | 1995 |
| Journal | J Exp Med | Volume | 181 |
| Issue | 2 | Pages | 787-92 |
| PubMed ID | 7836931 | Mgi Jnum | J:110779 |
| Mgi Id | MGI:3641036 | Doi | 10.1084/jem.181.2.787 |
| Citation | Martien van Santen H, et al. (1995) Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J Exp Med 181(2):787-92 |
| abstractText | Mice harboring a deletion of the gene encoding the transporter associated with antigen presentation-1 (TAP1) are impaired in providing major histocompatibility complex (MHC) class I molecules with peptides of cytosolic origin and lack stable MHC class I cell surface expression. They consequently have a strongly reduced number of CD8+ T cells. To examine whether selection of CD8+ T cells is dependent on TAP-dependent peptides, we partially restored MHC class I cell surface expression in TAP1-deficient mice by introduction of human beta 2-microglobulin. We show that selection of functional CD8+ T cells can be augmented in vivo in the absence of TAP1-dependent peptides. |
