| First Author | Gourapura RJ | Year | 2013 |
| Journal | PLoS One | Volume | 8 |
| Issue | 8 | Pages | e72867 |
| PubMed ID | 24009709 | Mgi Jnum | J:205941 |
| Mgi Id | MGI:5547453 | Doi | 10.1371/journal.pone.0072867 |
| Citation | Gourapura RJ, et al. (2013) Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression. PLoS One 8(8):e72867 |
| abstractText | CD1d molecules are structurally similar to MHC class I, but present lipid antigens as opposed to peptides. Here, we show that MHC class I molecules physically associate with (and regulate the functional expression of) mouse CD1d on the surface of cells. Low pH (3.0) acid stripping of MHC class I molecules resulted in increased surface expression of murine CD1d on antigen presenting cells as well as augmented CD1d-mediated antigen presentation to NKT cells. Consistent with the above results, TAP1-/- mice were found to have a higher percentage of type I NKT cells as compared to wild type mice. Moreover, bone marrow-derived dendritic cells from TAP1-/- mice showed increased antigen presentation by CD1d compared to wild type mice. Together, these results suggest that MHC class I molecules can regulate NKT cell function, in part, by masking CD1d. |
