| First Author | Datta SK | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 8 | Pages | 4102-10 |
| PubMed ID | 12682240 | Mgi Jnum | J:128788 |
| Mgi Id | MGI:3768020 | Doi | 10.4049/jimmunol.170.8.4102 |
| Citation | Datta SK, et al. (2003) A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 170(8):4102-10 |
| abstractText | Dendritic cells (DCs) are capable of cross-presenting exogenous Ag to CD8(+) CTLs. Detection of microbial products by Toll-like receptors (TLRs) leads to activation of DCs and subsequent orchestration of an adaptive immune response. We hypothesized that microbial TLR ligands could activate DCs to cross-present Ag to CTLs. Using DCs and CTLs in an in vitro cross-presentation system, we show that a subset of microbial TLR ligands, namely ligands of TLR3 (poly(inosinic-cytidylic) acid) and TLR9 (immunostimulatory CpG DNA), induces cross-presentation. In contrast to presentation of Ag to CD4(+) T cells by immature DCs, TLR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, and relies on cytosolic Ag processing machinery. |
