| First Author | Garbi N | Year | 2000 |
| Journal | Nat Immunol | Volume | 1 |
| Issue | 3 | Pages | 234-8 |
| PubMed ID | 10973281 | Mgi Jnum | J:64349 |
| Mgi Id | MGI:1889126 | Doi | 10.1038/79775 |
| Citation | Garbi N, et al. (2000) Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol 1(3):234-8 |
| abstractText | Tapasin is a component of the major histocompatibility complex (MHC) class I antigen-loading complex. Here we show that mice with a disrupted tapasin gene display reduced MHC class I expression. Cytotoxic T cell (CTL) responses to viruses are impaired, and dendritic cells of tapasin-deficient mice do not cross-present protein antigen via the MHC class I pathway, indicating a defect in antigen processing. Natural killer (NK) cells from tapasin-deficient mice have an altered repertoire and are self-tolerant. In addition, the repertoire of class I-bound peptides is altered towards less stably binding ones. Thus tapasin plays a role in CTL and NK immune responses and in optimal peptide selection. |
