| First Author | Swier K | Year | 1998 |
| Journal | J Immunol | Volume | 160 |
| Issue | 2 | Pages | 540-4 |
| PubMed ID | 9551884 | Mgi Jnum | J:45185 |
| Mgi Id | MGI:1194524 | Doi | 10.4049/jimmunol.160.2.540 |
| Citation | Swier K, et al. (1998) A critical, invariant chain-independent role for H2-M in antigen presentation. J Immunol 160(2):540-4 |
| abstractText | Antigen presentation by MHC class II (class II) is facilitated by the accessory molecules, invariant chain (Ii) and H2-M. Ii associates with class II during biosynthesis and promotes transport of class II to Ag-loading compartments. One function of H2-M is the removal of Ii fragments from MHC class II. We have previously demonstrated that Ii-deficient mice, unlike class II-deficient mice, are resistant to L. major infection. In the present study, we found that H2-M-deficient (H2- M0) mice were susceptible to progressive infection with L. major. The dispensability of Ii for control of L. major allowed genetic analysis of whether H2-M functions by association with or independently of Ii. In contrast to Ii-deficient (Ii0) mice, Ii0H2-M0 mice were as susceptible to L. major as H2-M0 mice. Thus, H2-M has an essential, Ii-independent function during presentation of microbial pathogens. |
