| First Author | Visvader JE | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 4 | Pages | 473-9 |
| PubMed ID | 9472016 | Mgi Jnum | J:46127 |
| Mgi Id | MGI:1197163 | Doi | 10.1101/gad.12.4.473 |
| Citation | Visvader JE, et al. (1998) Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev 12(4):473-9 |
| abstractText | The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast. |
